Nashville was founded by James Robertson, John Donelson, and a party of Wataugans in 1779, and was originally called Fort Nashborough, after the American Revolutionary War hero Francis Nash. Nashville quickly grew because of its prime location, accessibility as a riverport, and its later status as a major railroad center. In 1806, Nashville was incorporated as a city and became the county seat of Davidson County, Tennessee. In 1843, the city was named the permanent capital of the state of Tennessee.

By 1860, when the first rumblings of secession began to be heard across the South,antebellum Nashville was a very prosperous city. The city's significance as a shipping port made it a desirable prize as a means of controlling important river and railroad transportation routes. In February 1862, Nashville became the first state capital to fall to Union troops.

Though the Civil War left Nashville in dire economic straits, the city quickly rebounded. Within a few years, the city had reclaimed its important shipping and trading position and also developed a solid manufacturing base. The post-Civil War years of the late 19th century brought a newfound prosperity to Nashville. These healthy economic times left the city with a legacy of grand classical-style buildings, which can still be seen around the downtown area.

It was the advent of the Grand Ole Opry in 1925, combined with an already thriving publishing industry, that positioned it to become "Music City USA", and in the early 1960s the city was home to the main activity of the 1960s Civil Rights Movement (see History of Nashville, Tennessee). In 1963, Nashville consolidated its government with Davidson County and thus became the first major city in the United States to form a metropolitan government. Since the 1970s, the city has experienced tremendous growth, particularly during the economic boom of the 1990s under the leadership of Mayor (now-Tennessee Governor) Phil Bredesen, who made urban renewal a priority, and fostered the construction or renovation of several city landmarks, including the Country Music Hall of Fame, the Nashville Public Library downtown, the Sommet Center, and LP Field.